Experimental & molecular medicine
Megakaryocytic TGFβ1 orchestrates osteogenesis of LepR+ SSCs to alleviate radiation-induced bone loss.
Yong Tang, Jiulin Tan, Qixiu Yu, Wenxin Yang, Zhengrong Chen, Yueqi Chen, Qiankun Yang, Jie Zhang, Qijie Dai, Bo Yu, Yunqin Xu, Linying Zhou, Gang Wang, Ce Dou, Junping Wang
Published: 202610.1038/s12276-025-01612-z
Abstract
It has been reported that a close relationship exists between the hematopoietic and skeletal systems, and megakaryocytes (MKs) may play a role in maintaining bone homeostasis. However, the precise role and underlying mechanisms of MKs in osteogenesis…
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