Journal of the American Society for Mass Spectrometry
In-Source Fragmentation of Pyrrolidine-Containing KRAS Scaffolds Leads to Enhanced Structure Elucidation and Tandem Mass Spectral Quality.
Jessica L Ochoa, Christopher M Crittenden
Published: 202610.1021/jasms.5c00340
Abstract
The characterization of small-molecule therapeutics containing basic moieties, such as pyrrolidine groups common in KRAS G12C inhibitors, presents challenges for structure elucidation via tandem mass spectrometry (MS/MS). During fragmentation, the py…
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