Journal of the American Chemical Society
Nanobody-Based Bioconjugates as Potent and Broadly Active Inhibitors of HIV Entry.
Shubhra Jyoti Saha, Rashmi Kumariya, Phoenix A Davis, Emily Tourtellott, Nicole Doria-Rose, Carole A Bewley, Ross W Cheloha
Published: 202610.1021/jacs.5c22670
Abstract
We describe a semisynthetic strategy that unites the versatility of chemical peptide synthesis with the high affinity and specificity of antibody fragments to create conjugates with remarkably potent anti-HIV activity. Using site-selective enzymatic…
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