Journal of the American Chemical Society
A Hooker Oxygenase Archetype in Polyketide Biosynthesis Challenging the Baeyer-Villiger Monooxygenase Paradigm.
Heiner G Weddeling, Sven T Sowa, Elena Bialas, Sven Reese, Christian Merten, Markus Lill, Andreas Bechthold, Robin Teufel
Published: 202610.1021/jacs.5c21759
Abstract
Aromatic polyketides from Actinobacteria are structurally complex bioactive natural products with significant therapeutic potential, whose biosynthesis involves polyketide chain assembly, keto reduction, cyclization, and aromatization. This is follow…
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