Journal of the American Chemical Society
16-Step Scalable Chemoenzymatic Synthesis of Tetrodotoxin.
Chen Peng, Weilin Wu, Yuxuan Ye, Pengfei Hu
Published: 202610.1021/jacs.5c20700
Abstract
Tetrodotoxin (TTX) is a potent neurotoxin and a promising analgesic that selectively blocks voltage-gated sodium channels at nanomolar concentrations. Its complex structure features an octa-substituted cyclohexane core, excessive polar functionalitie…
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