Journal of the American Chemical Society
Near-Quantitative Formation of Imines in Water with Allosteric Control.
Tommaso Marchetti, Lorenzo Goldin, Benjamin M W Roberts, Deepak, Federico Rastrelli, Luca Gabrielli, Leonard J Prins
Published: 202610.1021/jacs.5c20524
Abstract
We demonstrate the near-quantitative formation of an imine bond in water under physiologically relevant conditions using a stoichiometric ratio of aldehyde and amine. To overcome the low hydrolytic stability of imines in water, a complementary metal…
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