Journal of the American Chemical SocietyCyclizationPeptidesLigasesAntibodiesHumans
Peptidyl Asparaginyl Ligase-Mediated Orthogonal Ligation at Non-Asx Peptide Bonds for d-Peptide Cyclization and Antibody Dual Labeling.
Hongxia Li, Yiyin Xia, Seetharamsing Balamkundu, Jiayong Liu, Fupeng Li, Xiaohong Zhang, Julien Lescar, James P Tam, Peter R Preiser, Chuan-Fa Liu
Published: 202610.1021/jacs.5c20426
Abstract
There is an increasing need to develop enzymatic methods for protein modification. PALs (peptidyl asparaginyl ligases) catalyze transpeptidation at the Asx (Asn or Asp) peptide bond with high efficiency and have been widely used for protein N- or C-t…
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