Journal of the American Chemical Society
Gold-Catalyzed Synthesis of sp3-Rich Nortricyclanes from Norbornenes.
Wenliang Wang, Zhensheng Jia, Hongliang Chen, Zhi Liu, Xiaoliang Yang, Yue Zhao, Jie Han, Weipeng Li, Jin Xie
Published: 202610.1021/jacs.5c20380
Abstract
Rigid, three-dimensional (3D) all-carbon sp3-rich skeletons have gained increasing attention as effective isosteric replacements for benzene rings in drug discovery, offering enhanced metabolic stability and lipophilicity. However, reliable and conci…
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