Journal of the American Chemical Society
Potent Racemic Antimicrobial Polypeptides Uncovered by a Stereochemical Series of Cationic d/l Backbones.
Swagatam Barman, Alimi Abiodun, Adam Parris, Xiaoming Yang, Md Waliullah Hossain, Prakash Nagarkatti, Mitzi Nagarkatti, Alan W Decho, Chuanbing Tang
Published: 202510.1021/jacs.5c19741
Abstract
Antimicrobial polypeptides (AMPs) are often engineered to adopt a secondary structure (e.g., α-helix, β-sheet, or turns), reinforcing the prevailing view that ordered conformations are preferred for enhanced activity. Here, we report a first-of-its-k…
Preview only. Read the full abstract at the source