Journal of the American Chemical SocietyCytochrome P-450 Enzyme SystemFree RadicalsHydrogen
Radical Clock Substrates Measure Nonstatistical Dynamical Effects in Cytochrome P450-Mediated C-H Functionalization Reactions.
Jyothish Joy, Daniel H Ess
Published: 202610.1021/jacs.5c19469
Abstract
Cytochrome P450 enzymes functionalize strong C-H bonds via a two-step hydrogen atom abstraction-radical rebound mechanism that involves a transient radical pair intermediate. Specially designed strained hydrocarbon substrates with predetermined rearr…
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