Journal of the American Chemical Society
Cu-Catalyzed Enantioselective and Divergent Synthesis of 5-5-Membered Atropisomers via Direct Atroposelective C-C/C-N Axial Bond Formation.
Guan-Zhi Liu, Fu-Cai Rao, Shi-Jie Liu, Wei-Lei Xiang, Peng-Cheng Qian, Hao Tang, Yu-Wu Zhong, Long-Wu Ye, Long Li
Published: 202610.1021/jacs.5c18193
Abstract
Due to its inherently more distant ortho-groups, lower rotational energy barrier, and less stable configuration, the catalytic asymmetric synthesis of 5-5-membered atropisomers has remained underdeveloped, particularly through direct atroposelective…
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