Journal of the American Chemical SocietyAnimalsProbioticsMiceGenetic CodeEscherichia coli
Genetic Code Expansion in Probiotics Enables the Secretion of Covalent Protein Drugs in Mice.
Kaiyi Wang, Yumeng Wu, Jiamin Shang, Lingxin Bu, Da Hu, Honglin He, Ruixuan Wang, Junyi Mao, Yao Yan, Jun Guan, Rui Wang, Huixin Luo
Published: 202610.1021/jacs.5c17978
Abstract
Oral delivery of therapeutic proteins remains a formidable challenge. Although engineered microbes have emerged as promising platforms for localized drug synthesis in the gut, their functional capacity has been restricted to the 20 canonical amino ac…
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