Journal of the American Chemical Society
An Engineered Nanovesicles-Based Lysosome-Targeting Protein Degradation Platform (NV-TACs) for Cancer Immunotherapy.
Youmei Xiao, Xiuman Zhou, Xiaoshuang Niu, Xiaoyun Ye, Danhong Chen, Qingyu Dong, Zhuoying He, Xin Yang, Mengfan Wang, Wenxuan Zeng, Ye Su, Feiyu Luo, Juan Liu, Yanfeng Gao
Published: 202610.1021/jacs.5c17801
Abstract
Lysosome-Targeting Chimeras (LYTAC) technology offers a revolutionary approach for specifically degrading extracellular and membrane proteins. However, current LYTAC platforms face multiple technical challenges, including ligand screening, linker opt…
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