Journal of the American Chemical SocietyHumansSignal TransductionReceptorsAdrenergicalpha-2
The Role of Intrinsically Disordered Domains in Regulating G Protein-Coupled Receptor Signaling.
Jun Xu, Ruoyi Qiu, Alexander M Garces, Harald Hübner, Xinyu Xu, Chengyu Hao, Dorothee Weikert, Peter Gmeiner, Michael T Lerch, Brian K Kobilka
Published: 202610.1021/jacs.5c17796
Abstract
The α2A adrenergic receptor (α2AAR) is a clinically important target for various diseases including hypertension, diabetes, and chronic pain. Here, using single-molecule fluorescence resonance energy transfer imaging, we show how agonist-specific act…
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