Journal of the American Chemical Society
Light-Driven Organocatalytic Birch Reduction for Late-Stage Drug Modification and sp3-Rich Spirocycle Synthesis.
Florian Schiel, Luca di Martile, Roberta Coccia, Andrea Palone, Magdalena Medrzycka, Laura Kqiku, Paulo Neves, Nunzio Matera, Antonio Misale, Paolo Melchiorre
Published: 202610.1021/jacs.5c17373
Abstract
The Birch reduction is a cornerstone transformation in synthetic chemistry, yet its widespread application is limited by harsh conditions, poor functional group tolerance, and safety concerns. Recent photochemical strategies have offered milder alter…
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