Journal of the American Chemical Society
Stereoselective Synthesis of Polyketide Motifs via Nickel-Catalyzed Multicomponent Coupling of Aldehydes, Dienes, and Boronic Acids: Reaction Development and Mechanistic Insights.
Jin-Tao Ma, Bo-Ying Yao, Tianze Zhang, Shi-Hui Cheng, Bin Xuan, Mengchun Ye, Qi-Lin Zhou, Li-Jun Xiao
Published: 202510.1021/jacs.5c17153
Abstract
Polyketides are renowned for their structural complexity and potent biological activity, yet efficient and stereocontrolled synthesis of their densely functionalized motifs remains a formidable challenge. Here, we report a nickel-catalyzed, stereosel…
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