Journal of the American Chemical SocietyPeptidesCyclicStaphylococcus aureusAnti-Bacterial AgentsBacillus subtilis
Automated Rapid Synthesis of High-Purity Head-to-Tail Cyclic Peptides via a Diaminonicotinic Acid Scaffold.
Feng Wan, Chengrui Hu, Pei Xie, Xingxing Yang, Xin He, Yourong Pan, Zuozhou Ning, Chengxi Li
Published: 202610.1021/jacs.5c16902
Abstract
Cyclic peptides uniquely integrate the structural stability and target specificity of biologics with the synthetic versatility of small molecules. However, their chemical synthesis has historically lagged behind ribosomal production in both speed and…
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