Journal of the American Chemical SocietyAnimalsHydrazonesMiceSpleenLipids
pH-Isomerizable Acylhydrazone-Based Ionizable Lipids for Spleen-Targeted mRNA Vaccines.
Xuqian Deng, Yan Li, Xiaolan Zhu, Yanlin Du, Hongli Chi, Ming Cheng, Yali Wang, Keli An, Penghui Zhang
Published: 202510.1021/jacs.5c16121
Abstract
Effectively and safely amplifying systemic immunity against heterogeneous and immunosuppressive cancers remains highly challenging. Here, we report a library of acylhydrazone-based ionizable lipids (AHzILs) that exploit pH-responsive E/Z isomerizatio…
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