Journal of the American Chemical SocietyHydrazinesModelsMolecularCrystallographyX-Ray
Structural and Mechanistic Insights into Bacterial Hydrazine Biosynthesis.
Guiyun Zhao, Huisi Huang, Yifan Li, Jian Yang, Yuan-Yang Guo, Liqiao Xu, Lu Wang, Jingkun Shi, Miaolian Wu, Yu Feng, Binju Wang, Zhi-Min Zhang, Yi-Ling Du
Published: 202510.1021/jacs.5c15949
Abstract
Nitrogen-nitrogen (N-N) bond-containing motifs are prevalent in both clinical drugs and natural products. Bacterial hydrazine synthetases catalyze N-N bond formation by coupling an amino acid and a hydroxylamine via a distinctive O-aminoacyl-hydroxyl…
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