Journal of the American Chemical SocietyHumansClick ChemistryCatalysisAntineoplastic AgentsProteolysis
In Situ PROTAC Synthesis Enabled by Pathologically Activated Bioorthogonal Catalysis for Precision Cancer Therapy.
Dilan Ouyang, Rongjin Yang, Yuhang Yao, Fang Jiang, Sijie Song, Yuheng Yang, Edikan A Ogunnaike, Zhitong Chen, Zhaowei Chen, Huanghao Yang
Published: 202510.1021/jacs.5c15945
Abstract
Proteolysis-targeting chimeras (PROTACs) have transformed therapeutic interventions by hijacking the ubiquitin-proteasome system. However, their broad application is hindered by inadequate cellular permeability and undesired off-tissue effects. Here,…
Preview only. Read the full abstract at the source