Journal of the American Chemical SocietyCopperHumansAntineoplastic AgentsIonophoresSaccharomyces cerevisiae
Potent Biological Activity by a Synthetic Cu(I) Cationophore Redistributing Intracellular Copper Pools.
Nathan Renier, Gianluca Weyckmans Mele, Pierre Lelièvre, Mélanie Boeckstaens, Roy Lavendomme, Akin Aydogan, Yannick Dussein, Peggy Charbonnier, Laurence Puillet Anselme, Benoit Chovelon, Hiram Castillo-Michel, Nikolay Tumanov, Johan Wouters, Lucie Sancey, Benoit Busser
Published: 202610.1021/jacs.5c15335
Abstract
Copper is an essential trace element for life and is present in the active site of various enzymes, whereas free copper is toxic to cells. Copper homeostasis is thus finely regulated, involving Cu(I) transporting membrane proteins Ctr1 and ATP7A/B. D…
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