Journal of the American Chemical Society
Chiral Lithium Amides as Key Reagents in Enantioselective Synthesis of 2-Alkylpyridines with Multiple Stereocenters.
Dyllan P Ly, Leroy Lu, Priya Kandiyal, Armen Zakarian
Published: 202510.1021/jacs.5c13977
Abstract
A direct enantioselective conjugate addition of 2-alkylpyridines enables efficient construction of complex functionalized pyridinyl scaffolds with contiguous stereocenters. This method leverages chiral lithium amides as traceless stereodirecting auxi…
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