Journal of the American Chemical SocietyHumansTetraspanin 29Photoaffinity LabelsAntineoplastic AgentsCell Line
Photoaffinity Labeling Strategy Reveals Tetraspanin CD9 as a Transient Target of Anticancer Yaku'amide B.
Junhao Fu, Koichi Kamiya, Kai Kitamura, Ryo Kawahara, Wataru Shihoya, Osamu Nureki, Shoichi Hosoya, Reiko Nakagawa, Tetsuo Mashima, Hiroaki Itoh, Masayuki Inoue, Kaori Sakurai
Published: 202610.1021/jacs.5c13808
Abstract
Innovative chemical strategies are needed to understand the molecular targets of natural products, especially when they engage with multiple targets via transient interactions. Yaku'amide B (1), an anticancer natural product, inhibits mitochondrial F…
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