Journal of the American Chemical SocietyHIV-1Anti-HIV AgentsCryoelectron MicroscopyHumansCyclopropanes
Distinct Target Site of Lenacapavir in Immature HIV-1 and Concurrent Binding with the Maturation Inhibitor Bevirimat.
Chunxiang Wu, Megan E Meuser, Juan S Rey, Hamed Meshkin, Rachel Yang, Swapnil C Devarkar, Christian Freniere, Jiong Shi, Christopher Aiken, Juan R Perilla, Yong Xiong
Published: 202510.1021/jacs.5c13735
Abstract
HIV-1 inhibitors, such as bevirimat (BVM) and lenacapavir (LEN), significantly reduce the production and maturation of infectious virions. However, their mechanisms remain unclear due to the absence of high-resolution structures for BVM in complex wi…
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