Journal of the American Chemical SocietyPolyketidesPolyketide SynthasesSubstrate SpecificityThiolester Hydrolases
Establishing Selectivity Trends with Reactions of Thioesterases and Semi-Synthetic Polyketides.
Zachary C Litman, Yuanhuang Chen, David H Sherman
Published: 202510.1021/jacs.5c11177
Abstract
Polyketides are a diverse class of natural products with a wide range of therapeutic properties. They have been widely used in clinical settings as antibiotics, antifungals, anticancer agents, and immunosuppressants. A major subset of these molecules…
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