Regiodivergent Access to α- and β-Amino Acids via Solvent-Controlled Rh-Catalyzed Carboamidation of β,γ-Unsaturated Carboxylic Acids.

Non-natural α- and β-amino acids are pivotal building blocks in medicinal chemistry and bioactive molecule discovery. Herein, we report a rhodium-catalyzed, solvent-directed, regiodivergent carboamidation of β,γ-unsaturated alkenyl carboxylic acid fo…

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