Journal of the American Chemical SocietySulfonamidesHumansMolecular StructureLigandsAgammaglobulinaemia Tyrosine Kinase
β-Fluorovinylsulfonamide as a Highly Reactivity- and Structure-Tunable Electrophile for Covalent Targeting of Proteins.
Shunsuke Watanabe, Keisuke Tokunaga, Yudai Tanaka, Yuya Hirose, Emi Mishiro-Sato, Keiko Kano, Kaori Sasaki-Tabata, Yuri Kato, Motohiro Nishida, Naoya Shindo, Akio Ojida
Published: 202510.1021/jacs.5c07422
Abstract
Covalent targeting of proteins with small molecule probes is a powerful approach for analyzing and manipulating biological functions. Recent advancements in the design of target selective covalent ligands further expand the scope of accessible protei…
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