ACS synthetic biologyCRISPR-Cas SystemsGene EditingDeep LearningCRISPR-Associated ProteinsSoftware
TEMC-Cas: Accurate Cas Protein Classification via Combined Contrastive Learning and Protein Language Models.
Xingyu Liao, Yanyan Li, Yingfu Wu, Long Wen, Minghui Jing, Bolin Chen, Xingyi Li, Xuequn Shang
Published: 202510.1021/acssynbio.5c00631
Abstract
The accurate classification of Cas proteins is crucial for understanding CRISPR-Cas systems and developing genome-editing tools. Here, we present TEMC-Cas, a deep learning framework for accurate classification of Cas proteins that combines a finely t…
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