ACS synthetic biologyAnimalsVaccinesConjugateMiceCell-Free System
A Scalable Cell-Free Manufacturing Platform for Two-Step Bioproduction of Immunogenic Conjugate Vaccines.
Derek A Wong, Rochelle Aw, Sophia W Hulbert, Yufan Qin, Zachary M Shaver, Kathryn A Myers, Ashty S Karim, Matthew P DeLisa, Michael C Jewett
Published: 202510.1021/acssynbio.5c00569
Abstract
Rapid and decentralized vaccine production is essential to ensure global preparedness against emerging and re-emerging infectious diseases. Cell-free gene expression systems, which can be freeze-dried for long-term storage and reactivated for point-o…
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