ACS synthetic biologyCephalosporinsMetabolic EngineeringAcremoniumPeptidesPenicillium chrysogenum
Enhancing Cephalosporin C Biosynthesis through a 2A Peptide-Based Multigene Coexpression System.
Zhen Chen, Yifan Li, Xiaorong Wei, Wei Hong, Yuanxin Guo, Haifeng Hang, Ju Chu, Xiwei Tian
Published: 202510.1021/acssynbio.5c00543
Abstract
Cephalosporin C (CPC) is a natural product that serves as the key precursor for various semisynthetic cephalosporins. Its industrial production primarily relies on Acremonium chrysogenum. However, as the exclusive microbial strain used for large-scal…
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