ACS sensorsGlioblastomaHumansViscosityCell LineTumor
Ring-Shaped Open Microfluidic Platform Reveals Viscosity-Driven Mechanical Priming of Glioblastoma Cells.
Chao Xu, Chuan Shao, Haotian Jiang, Cheng Zeng, Gang Zhang, Xingyi Li, Yigang Shen, Yaxiaer Yalikun, Ming Li, Xun Liu, Nan Wu, Tao Tang
Published: 202510.1021/acssensors.5c02716
Abstract
The glioblastoma (GBM) tumor microenvironment is characterized by abnormally high extracellular viscosity, particularly at the invasive tumor margins. While elevated viscosity is thought to impede migration, paradoxically, GBM cells often exhibit enh…
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