Zn(OAc)2·2H2O‑Catalyzed Sulfurization Reaction of Alkenes: A Selective and Direct One-Pot Synthesis of β‑Hydroxysulfides and Thioetherpyridines.

β-Hydroxysulfides are valuable intermediates in pharmaceutical and synthetic chemistry. In this study, we present an efficient method for synthesizing β-hydroxysulfides via the radical pathway for sulfurization reaction of alkenes using Zn-(OAc)2·2H2O as an inexpensive and environmentally friendly catalyst, yielding products in good to excellent yields. Notably, vinylpyridine serves as an effective substrate, leading to the formation of unique thioetherpyridine products in high yields. These products are versatile and can undergo additional transformations, broadening their synthetic utility. The advantages of this method include a broad substrate scope, mild conditions, and high compatibility with various functional groups.