ACS nanoPhotochemotherapyHumansPhotosensitizing AgentsInfrared RaysImmunotherapy
Ion-Pairing Therapeutic Agents to Overcome Immune Resistance for Enhancing Type I Near-Infrared Photodynamic Immuno/Chemotherapy.
Haoran Hou, Hanhan Lu, Tai Sun, Siwen Wei, Yutong Shao, Gaobo Hong, Yanliang Zhao, Jianjun Du, Yingnan Wu, Fengling Song, Xiaojun Peng
Published: 202610.1021/acsnano.5c17321
Abstract
Photodynamic therapy (PDT) is well-known to induce tumor immunotherapy by immunogenic cell death (ICD). However, oxygen-dependent Type II PDT paradoxically exacerbates hypoxia, driving PD-L1-mediated immune evasion and undermining therapeutic efficac…
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