ACS nanoDependovirusNanoporesGenetic VectorsCapsidQuality Control
Mechanisms of Adeno-Associated Virus Serotype 9 Vector Characterization and Quality Control through Solid-State Nanopores.
Navod Thyashan, Janeesha Manawasinghe, Chaoming Gu, Santosh Khatri, Christopher Nelson, Merve Emecen Sanli, Steven J Gray, Sangyoup Lee, Prashanta Dutta, George Alexandrakis, Min Jun Kim
Published: 202610.1021/acsnano.5c16533
Abstract
Adeno-associated virus (AAV) vectors are excellent gene-delivery carriers in gene therapy; however, improperly packaged capsids produced during manufacturing can reduce potency and raise safety concerns. We introduce a machine-learning-assisted, low-…
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