ACS nanoPyroptosisMitophagyInfrared RaysHumansMice
Near-Infrared-Triggered Photoresponsive Nanobombs Overcome Tumor Immunosuppression through Coordinated Pyroptosis Activation and Mitophagy Blockade.
Shanshan Zhang, Mengjie Ye, Linlin Han, Hengbo Zhang, Qihan Wang, Menglin Zhang, Fanpeng Ran, Xiaoxiao Shi, Zhigang Xu
Published: 202510.1021/acsnano.5c16196
Abstract
Solid tumors resemble fortified hypoxic bastions with multifaceted defense mechanisms, wherein the synergistic interplay of hypoxia and immunosuppressive networks severely limits conventional therapies. While reactive oxygen species (ROS)-induced pyr…
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