ACS nanoFemaleAnimalsSympathetic Nervous SystemBreast NeoplasmsImmunotherapy
Enhancing Breast Cancer Immunotherapy by Suppressing Sympathetic Nervous System-Driven T-Cell Exhaustion and Promoting T-Cell Priming and Trafficking.
Lin Gao, Zhiyuan Luo, Lei Dong, Chanchan Gao, Xinyu Zhang, Xueqing Yong, Hui Yang, Ying Zhou, Yue Li, Tingting Liu, Gaolin Liang, Mohd Muddassir, Yini Zhu, Jinbing Xie
Published: 202610.1021/acsnano.5c16178
Abstract
Immunotherapy has transformed cancer treatment, yet its efficacy in solid tumors such as breast cancer remains limited by weak T cell priming, impaired trafficking, and functional exhaustion within the tumor microenvironment. Sympathetic nervous syst…
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