ACS nanoImmunotherapyAnimalsMiceTumor MicroenvironmentCancer Vaccines
Dual-Powered Nanomotor In Situ Vaccine with Tumor-Confined Penetration and Acidity Neutralization Boosts Stimulator of Interferon Genes-Mediated Immunotherapy.
Jianing Li, Yuanting Zhang, Weidong Wang, Yimin Gong, Yaming Zhou, Yannan Yang
Published: 202610.1021/acsnano.5c14053
Abstract
Despite its great potential, the clinical outcome of an in situ vaccine (ISV) remains limited due to inadequate immune activation within the tumor microenvironment (TME). This limitation is largely attributed to the dense tumor matrix and the immunos…
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