ACS nanoAnimalsTumor MicroenvironmentCancer-Associated FibroblastsMiceHumans
In Situ Remodeling of Tumor Microenvironment via Specific Cancer-Associated Fibroblasts Subtype Engineering to Boost Antitumor Immunity.
Shuang Chang, Qing Chen, Guannan Guan, Ming Zhao, Genshen Ding, Yibo Yuan, Yueci Sun, Fei Yan, Xinying Ma, Guangyong Chen, Zhengui Yuan, Xiaoyue Bao, Dawei Chen, Lu Xu, Haiyang Hu
Published: 202510.1021/acsnano.5c10776
Abstract
Cancer-associated fibroblasts (CAFs) are heterogeneous and critical drivers of tumor progression, yet engineering tumor-promoting CAF subtypes in situ offers an untapped therapeutic opportunity. Herein, we verify that the FAP+αSMA+ CAFs subtype in th…
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