ACS infectious diseasesMethicillin-Resistant Staphylococcus aureusRiboswitchOligonucleotidesAntisenseHumans
Rational Design of Chimeric Antisense Oligonucleotides that Target FMN Riboswitch mRNAs and Inhibit the Growth of Methicillin-Resistant Staphylococcus aureus.
Vanya N Dyakova, Martina Traykovska, Nikolet Pavlova, Dimitrios Kaloudas, Robert Penchovsky
Published: 202610.1021/acsinfecdis.5c00779
Abstract
Antimicrobial resistance poses a significant threat to medicine, exemplified by methicillin-resistant Staphylococcus aureus (MRSA), which is resistant to nearly all antibiotics. We designed chimeric antisense oligonucleotides (ASOs) targeting the con…
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