ACS infectious diseasesAnimalsCarbonic Anhydrase InhibitorsMiceEnterococcus faeciumDisease Models
Bacterial Carbonic Anhydrase Inhibitor CAI0019 Demonstrates Efficacy in Enterococcus faecium Septicemic Peritonitis Mouse Model While Sparing the Microbiome.
Nader S Abutaleb, Katrina J Holly, Carolyn K Metcalfe, Ahmed A Abouelkhair, Prabhakara R Tharra, Annadka Shrinidhi, Abdallah S Abdelsattar, Victoria Burgo, Glory Melotte, Tomi Akin-Olabiyi, Sean Knoblauch, Ramanujam Ramaswamy, Che Woodson, Venkatesh P Thirumalaikumar, J Alejandra Rodriguez
Published: 202610.1021/acsinfecdis.5c00736
Abstract
Vancomycin-resistant enterococci are multidrug-resistant bacteria that as of 2021 continue to pervade the U.S. healthcare system as the second-most prevalent source of healthcare-acquired infections behind Escherichia coli. Given the limited treatmen…
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