ACS infectious diseases
Broad-Spectrum Naphthyl-Substituted Diaminoquinolines Inhibiting the AdeG Efflux Pump of Acinetobacter baumannii.
Rushikesh Tambat, Aysegul Saral Sariyer, Emrah Sariyer, Marcela Olvera, Mithila Farjana, Napoleon D'Cunha, John K Walker, Helen I Zgurskaya
Published: 202610.1021/acsinfecdis.5c00722
Abstract
AdeFGH and AdeIJK, the two homologous multidrug efflux pumps of the resistance-nodulation-division superfamily of transporters, play distinct roles in Acinetobacter baumannii physiology and antibiotic resistance. Unlike ubiquitous AdeIJK, AdeFGH is s…
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