ACS infectious diseasesNorovirusPeptidomimeticsAntiviral AgentsCoronavirus 3C ProteasesSARS-CoV-2
Broad-Spectrum Peptidomimetic Inhibitors of Norovirus and Coronavirus 3C-like Proteases.
Margaret A Brimble, Louise A Stubbing, Yann O Hermant, Sung-Hyun Yang, Jonathan G Hubert, Esperanza S Pearl, Alice M McSweeney, Vivienne L Young, Ashley C Campbell, Helen K Opel-Reading, Geena M McKenzie-Goldsmith, Lohitha Putha, Roman Mortuza, Hong Wang, Brett L Hurst
Published: 202610.1021/acsinfecdis.5c00680
Abstract
The cysteine 3C-like proteases (3CLpro) of caliciviruses, coronaviruses, and picornaviruses are essential for viral replication. In this study, we report the development of potent broad-spectrum peptidomimetic antiviral agents that target the 3CLpro…
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