ACS infectious diseases
Decoding Ceftazidime-Avibactam Resistance in Newly Identified Klebsiella pneumoniae Carbapenemase (KPC) 107 Variant by Modulating the Active Site Environment.
Riya Karan, Kunal Dhankhar, Adarsh Singh, Saroj Kumar Panda, Tanmoy Sen, Parth Sarthi Sen Gupta, Saugata Hazra
Published: 202510.1021/acsinfecdis.5c00288
Abstract
Antibiotic resistance is a serious health concern worldwide, predominantly driven by β-lactamase enzymes that can inactivate most prescribed β-lactam drugs. Carbapenemases are specialized β-lactamases that hydrolyze carbapenems, considered last-resor…
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