ACS chemical neuroscienceAnimalsAlzheimer DiseaseBrain-Derived Neurotrophic FactorNLR FamilyPyrin Domain-Containing 3 Protein
Santonin Attenuates Alzheimer's-Like Pathology via Multitarget Modulation of the NLRP3 Inflammasome, BDNF Signaling, and Amyloidogenic Pathways: An Integrated Experimental and Computational Study.
Muhammad Noman, Halima Qadir, Sagheer Ahmed, Najeeb Ur Rehman, Fawad Ali Shah, Muhammad Riaz, Nadeem Ahmad, Zaheer Ul-Haq, Nadeem Irshad
Published: 202610.1021/acschemneuro.5c00957
Abstract
Alzheimer's disease (AD) is a neurodegenerative disorder and the predominant cause of dementia, characterized by amyloid β (Aβ) plaques and tau tangles that disrupt neurons in memory-related brain regions. This study explores the therapeutic potentia…
Preview only. Read the full abstract at the source