ACS chemical neuroscienceAnimalstau ProteinsHumansTauopathiesMice
In Vitro and In Vivo Evaluation of Small-Molecule Disassemblers of Pathological Tau Fibrils.
Hope Pan, Xinyi Cheng, Jeffrey Zhang, Ke Hou, Kevin A Murray, Kapil Manglani, Cansheng Zhu, Hung-Kai Hsu, Marisa Mekkittikul, Tyler Halladay, Hilda Mirbaha, Gazmend Elezi, Romany Abskharon, Michael R Sawaya, Alexander Bombino
Published: 202610.1021/acschemneuro.5c00940
Abstract
Aggregation of the microtubule-binding protein tau is the histopathological hallmark of Alzheimer's disease (AD) and other neurodegenerative diseases, which are collectively known as tauopathies. Tau aggregation in AD patients is correlated with neur…
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