ACS chemical neuroscience
A Dual Approach To Combat Alzheimer's Disease through Concomitant hBChE Inhibition and S1R Activation.
Kora Reichau, Lucie Crouzier, Eleonora Poeta, Tina Gehrig, Eva Schaller, Liga Zvejniece, Johann Meunier, Christoph Sotriffer, Barbara Monti, Tangui Maurice, Michael Decker
Published: 202610.1021/acschemneuro.5c00921
Abstract
Alzheimer's disease (AD) remains an incurable neurodegenerative disorder, requiring novel therapeutic strategies. We developed multitarget-directed ligands designed to inhibit human butyrylcholinesterase (hBChE) and activate the sigma-1 receptor (S1R…
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