ACS chemical neuroscienceHumansalpha7 Nicotinic Acetylcholine ReceptorAllosteric RegulationNicotinic AntagonistsReceptors
Isodrimenine Derivatives Selectively Inhibit Human α7-Containing Nicotinic Acetylcholine Receptors via Negative Allosteric Modulation.
Han-Shen Tae, Marcelo O Ortells, Alexandru Ciocarlan, Aculina Aricu, Lidia Lungu, Svetlana Blaja, David J Adams, Hugo R Arias
Published: 202610.1021/acschemneuro.5c00862
Abstract
Drimane sesquiterpenoids are biologically active compounds found in plants, fungi, and marine organisms. Three isodrimenine derivatives, 5,6-dehydro-7-keto-isodrimenine (DH7KID), 7-keto-isodrimenine (7KID), and 7-acetoxy-isodrimenine (7AID), belongin…
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