ACS chemical neuroscience
Differentiating Alzheimer's Aβ Isoforms Coaggregated in Cerebrospinal Fluid via Single-Particle Imaging.
Lily Henry, Shayon Bhattacharya, Talia Bergaglio, Dorothea Pinotsi, Peter Niraj Nirmalraj
Published: 202610.1021/acschemneuro.5c00692
Abstract
Amyloid polymorphism can reflect Alzheimer's disease (AD) stages. This paper demonstrates that amyloid β (Aβ) peptides, primarily Aβ-40 and Aβ-42 (implicated in AD pathology), present in cerebrospinal fluid (CSF), can be differentiated, and their mor…
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