ACS chemical neuroscienceAnimalsMorphinePruritusInjectionsSpinal
Intrathecal Injection of Morphine Induces Pruritus via the NMDAR-Akt Signaling Pathway.
Jing Qin, Xue Wang, Xuedong Wang, Fan Liu, Chunsheng Feng
Published: 202510.1021/acschemneuro.5c00656
Abstract
Neuraxial opioids are routinely administered for pain management, but patients unavoidably suffer from irritating itch. The NMDAR-Akt signaling pathway is strongly implicated in morphine-induced tolerance and pain pathogenesis. Given that pain and it…
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