ACS chemical neuroscienceAnimalsHydrogen SulfideLipopolysaccharidesMiceDepression
Design and Synthesis of a Multifunctional Hydrogen Sulfide Donor and Its Application in Depressive-Like Behavior in Mice Induced by Lipopolysaccharide.
Xin Hao, Changming Wang, Saiguo Liu, Peiquan Yu, Youzhen Ma, Yi Liu
Published: 202510.1021/acschemneuro.5c00579
Abstract
Depression, characterized by a persistent low mood and apathy, is classified as a mental illness. Lipopolysaccharide (LPS), an inflammatory inducer, reduces plasma concentrations of hydrogen sulfide (H2S) and gamma-aminobutyric acid (GABA) in mice, r…
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